The Role of Cell Migration and Chimerism in Organ Transplant Acceptance and Tolerance Induction.

The essence of this presentation is that under effective immunosuppression, there is a migration of sessile (passenger) leukocytes (prominently but not limited to dendritic cells) from the graft into ubiquitous recipient tissues, and replacement of these cells in the graft by similar leukocytes from the recipient. The consequence is a body wide engagement of donor and recipient cells followed, we believe, with variable donor and recipient-specific nonreactivity that mayor may not require lifetime immunosuppression for stabilityl (Fig. 1).